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Characterizing the spatio-temporal dynamics of the epileptogenic process with nonlinear EEG analyses

TitleCharacterizing the spatio-temporal dynamics of the epileptogenic process with nonlinear EEG analyses
Publication TypeBook Chapter
Year of Publication2002
AuthorsElger CE, Mormann F, Kreuz T, Andrzejak RG, Rieke C, Sowa R, Florin S, David P, Lehnertz K
EditorTetzlaff R
Book TitleCELLULAR NEURAL NETWORKS AND THEIR APPLICATIONS
Pagination228-242
PublisherJohann Wolfgang Goethe Univ; IEEE Circuits & Syst Soc; German Natl Sci Fdn; Off Naval Res, Int Field Off; USAF, European Off Aerosp Res & Dev
ISBN Number981-238-121-X
Abstract

In this overview we present our work investigating the spatio-temporal dynamics of the epileptogenic process using time series analysis techniques derived from the theory of nonlinear dynamics. Apart from a localization of epileptic foci in different anatomical locations during the seizure-free interval we discuss possibilities for seizure prediction, a field that represents one of the greatest challenges in epileptology. The unequivocal definition of a pre-seizure state of a sufficient length would enable investigation of basic mechanisms leading to seizure initiation in humans and provide a basis for the development of adequate seizure prevention strategies.